By Joseph Bertone DVM MS Diplo. ACVIM, Linda J. I. Horspool BVMS PhD DipECVPT MRCVS
Targeting the healing demanding situations on the topic of the horse's targeted anatomy and body structure, this entire textual content is the 1st equine particular, scientific pharmacology and therapeutics textual content on hand! masking the rules and use of pharmaceutical items within the equine, this useful reference is equipped by means of both drug classification or, the place extra pertinent, via method. It additionally presents finished info on drug dose premiums that's summarized alphabetically on the finish of the booklet as a formulary of universal drugs.
- The newest details on healing thoughts for horses is equipped, together with items lately brought at the market.
- An alphabetic, established formulary at the back of the e-book presents readers with a convenient, fast reference.
- Content is obviously go referenced, making details concise and simple to find.
- A sensible structures technique comes in handy to practitioners and scholars alike.
- Comprehensive discussions offer a valid foundation for making healing judgements in equine practice.
- Well-referenced content material bargains readers a great history in scientific pharmacology and therapeutics.
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Extra info for Equine Clinical Pharmacology, 1e
Potentiated sulfonamides are usually active against streptococci, staphylococci, C. , Nocardia spp. and some Gram-negative bacteria, including strains of E. coli and Shigella, Salmonella, Klebsiella, Pasteurella and Proteus spp. They are considered ineffective against most obligate anaerobes and should not be used to treat serious anaerobic infections. Trimethoprim and pyrimethamine are diaminopyrimidines that are used most commonly in combination with the sulfonamides and the MIC of pathogens is generally lowered in such a combination.
However, folate administration did not prevent fetal defects (renal and bone marrow hypoplasia) in foals born to one group of treated pregnant mares. Despite folate supplementation, both mares and foals had lower than normal serum folate levels. Folate and the diaminopyrimidines use the same intestinal carrier for absorption, so if used concurrently they should be administered at least 2 h apart. The risk of congenital defects should be considered when treating pregnant mares with potentiated sulfonamides.
Anemia and thrombocytopenia develop in dogs administered high doses of ceftiofur for an extended period. Horses may develop diarrhea after treatment with ceftiofur. The currently available cephalosporins are considered to be potentially nephrotoxic, either via the deposition of immune complexes in the glomerular basement membrane or as a direct effect that leads to acute tubular necrosis. However, animal studies have shown that the cephalosporins protect against nephrotoxicity. In human medicine, it is recommended that cephalosporins not be used in conjunction with aminoglycosides.